Locally advanced breast cancer.
نویسندگان
چکیده
The multidisciplinary management of patients with locally advanced breast cancer (LABC) has evolved over the last three decades. The introduction of chemotherapy (CT) and endocrine therapy in conjunction with surgery and radiation therapy (XRT) have changed the natural history of this disease. The authors discuss the role of the taxanes, novel endocrine therapy, and high-dose CT programs in the management of LABC. Indications for breast-conserving surgery are presented. The role of prognostic and predictive tumor markers in LABC is discussed.
منابع مشابه
Postmastectomy radiation therapy in locally advanced breast cancer.
Despite wide efforts for early detection of breast cancer using screening mammography, locally advanced breast carcinomas account for a remarkable proportion of all breast carcinomas, particularly in developing countries. Locally advanced breast cancer may have widely different clinical and biological features. Radiotherapy plays an important role in the management of locally advanced breast ca...
متن کاملDiagnosis and Staging
1. Distinguish between women at various risks of breast cancer recurrence and apply differences to management strategies accordingly. 2. Develop evidence-based treatment plans for the management of early and locally advanced breast cancer. 3. Assess the role of neoadjuvant and adjuvant chemotherapy in early and locally advanced breast cancer. 4. Apply pharmacokinetic and pharmacodynamic princip...
متن کاملUpdate in the treatment of locally advanced breast cancer: a multidisciplinary approach.
Locally advanced breast cancer represents a wide variety of neoplasms and constitutes approximately 10%-20% of the newly diagnosed breast cancers. These cancers may have widely different clinical and biological characteristics. According to the American Joint Committee on Cancer (AJCC) staging system, all of stage III disease is considered locally advanced. The clinical treatment of locally adv...
متن کاملWeekly taxane–anthracycline combination regimen versus tri-weekly anthracycline-based regimen for the treatment of locally advanced breast cancer: a randomized controlled trial
BACKGROUND Extensive studies have confirmed the efficacy of taxanes in combination with anthracycline-based chemotherapy on breast cancer. However, few studies have assessed the efficacy of weekly taxane-anthracycline regimens on locally advanced breast cancer. This study was to compare the efficacy and safety of a weekly taxane-anthracycline regimen with those of tri-weekly anthracycline-based...
متن کاملبررسی مشخصات دموگرافیک و بالینی بیماران مبتلا به سرطان پستان در ارومیه، روش غربالگری مناسب کدام می تواند باشد؟
Received: 3 March, 2010 Accepted: 19 May, 2010 AbstractBackground &Aims: Breast cancer after skin cancer is the most common type of cancer in women and is not preventable, but early detection through mammography improves treatment options, success, and survival. Breast cancer is the third most common malignant neoplasm in Iran (10% of all cancers). The aim of this study was to determine the age...
متن کاملEvaluation of Clinical and Pathological Response after Two Cycles of Neoadjuvant Chemotherapy on Sudanese Patients with Locally Advanced Breast Cancer
BACKGROUND The use of neoadjuvant chemotherapy in treating breast cancer has shown efficacy in downstaging primary tumors, and allows breast conservative surgery to be performed instead of mastectomy. This study aims to evaluate patterns of clinical and pathological response after two cycles of neoadjuvant chemotherapy in patients with locally advanced breast cancer. MATERIALS AND METHODS Thi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Hematology/oncology clinics of North America
دوره 13 2 شماره
صفحات -
تاریخ انتشار 1996